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@@ -15,7 +15,7 @@ CALDER is a Hi-C analysis tool that allows: (1) compute chromatin domains from w
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## (A note on the performance of Calder vs PC-based approach)
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-* PC1 (sometimes PC2) of the correlation matrix was typically used to define A/B compartment. We found Calder demonstrates superior robustness over PC-based approach in identifying meaningful compartments, particularly when faced with complex chromosomal structural variations (figure on the left) and loose interaction between the p and q arms (figure on the right)
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+* PC1 (sometimes PC2) of the correlation matrix was typically used to define A/B compartment. We found Calder demonstrates superior robustness over PC-based approach in identifying meaningful compartments, particularly when faced with complex chromosomal structural variations (figure on the left) or loose interaction between the p and q arms (figure on the right)
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![Alt text](./img/Hela_chr11_and_RWPE1_chr9_pq.png "Hela_chr11_and_RWPE1_chr9_pq")
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