| 
					
				 | 
			
			
				@@ -14,7 +14,7 @@ CALDER is a Hi-C analysis tool that allows: (1) compute chromatin domains from w 
			 | 
		
	
		
			
				 | 
				 | 
			
			
				 * Aggregated all chromosome output into a single file 
			 | 
		
	
		
			
				 | 
				 | 
			
			
				  
			 | 
		
	
		
			
				 | 
				 | 
			
			
				 ## Introduction of opitimized bin_size selection 
			 | 
		
	
		
			
				 | 
				 | 
			
			
				-('bin_size' is equivalent to 'resoltution') 
			 | 
		
	
		
			
				 | 
				 | 
			
			
				+(Trough out the CALDER package, 'bin_size' means the size of the Hi-C contacts is binned, and is equivalent to 'resoltution' in the literature) 
			 | 
		
	
		
			
				 | 
				 | 
			
			
				  
			 | 
		
	
		
			
				 | 
				 | 
			
			
				 We added an opitimized bin_size selection strategy for the purpose of calling reliable compartments at high resolution.  
			 | 
		
	
		
			
				 | 
				 | 
			
			
				  
			 |