Update README.md

README.md

@@ -5,7 +5,7 @@ CALDER is a Hi-C analysis tool that allows: (1) compute chromatin domains from w
 
 ![Alt text](./img/CALDER_methods.png "CALDER methods")
 
-Calder links chromatin 3D organization to genomic function:
+Calder connects chromatin 3D organization to genomic function:
 ![Alt text](./img/CALDER_features.png "CALDER features")
 
 
@@ -21,7 +21,7 @@ Below we introduce two main updates:
 
 ### (1) Opitimized `bin_size` selection
 
-Due to reasons such as low data quality or large scale structrual variation, compartments can be unreliablly called at one `bin_size` (equivalent to `resoltution` in the literature) but correctly called at another `bin_size`. We added an opitimized `bin_size` selection strategy to call reliable compartments. This strategey is based on the observation from our large scale compartment analysis (https://www.nature.com/articles/s41467-021-22666-3) that, although compartments can change between different conditions, their overall correlation `cor(compartment_rank_1, compartment_rank_2)` is high (> 0.4).
+Due to reasons such as low data quality or large scale structrual variation, compartments can be unreliablly called at one `bin_size` (equivalent to `resoltution` in the literature) but properly called at another `bin_size`. We added an opitimized `bin_size` selection strategy to call reliable compartments. This strategey is based on the observation from our large scale compartment analysis (https://www.nature.com/articles/s41467-021-22666-3), that, although compartments can change between different conditions, their overall correlation `cor(compartment_rank_1, compartment_rank_2)` is high (> 0.4).
 <br>
 <br>
 **The strategy**: given a `bin_size` specified by user, we call compartments with extended `bin_sizes` and choose the smallest `bin_size` such that no bigger `bin_size` can increase the compartment correclation with a reference compartment more than 0.05. For example, if correclation for `bin_size=10000` is 0.2 while for `bin_size=50000` is 0.6, we are more confident the latter is more reliable; if correclation for `bin_size=10000` is 0.5 while for `bin_size=50000` is 0.52, we would choose the former as it has higher resolution.