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For the computational requirement, running CALDER on the GM12878 Hi-C dataset at bin size of 40kb took **36 minutes** to derive the chromatin domains and their hierarchy for all chromosomes (i.e., CALDER Step1 and Step2); **13 minutes** to derive the nested sub-domains (i.e., CALDER Step3). At the bin size of 10kb, it took **1 h 44 minutes and 55 minutes** correspondingly (server information: 40 cores, 64GB Ram, Intel(R) Xeon(R) Silver 4210 CPU @ 2.20GHz). The evaluation was done using a single core although CALDER can be run in a parallel manner.
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